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Opposing roles for protein tyrosine phosphatases SHP2 and PTPN12 in breast cancer

Aceto, Nicola. Opposing roles for protein tyrosine phosphatases SHP2 and PTPN12 in breast cancer. 2011, Doctoral Thesis, University of Basel, Faculty of Science.

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Official URL: http://edoc.unibas.ch/diss/DissB_9510

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Abstract

Breast cancer is the most common malignancy among women. It is a very heterogeneous disease that progresses to metastasis, a usually fatal event. The cellular and biochemical mechanisms orchestrating this progression remain largely elusive. Therefore, the elucidation of the oncogenic and tumor-suppressive networks of cancer cells is fundamental to the development of targeted therapies for this presently incurable disease. We demonstrate a fundamental role for protein-tyrosine phosphatases SHP2 and PTPN12 in breast cancer. These results should lead to important therapeutic advances for the treatment of this disease.
Advisors:Bentires-Alj, Mohamed
Committee Members:Hynes, Nancy and Christofori, Gerhard M.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Biochemistry (Spiess)
UniBasel Contributors:Christofori, Gerhard M.
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:9510
Thesis status:Complete
Number of Pages:146 S.
Language:English
Identification Number:
edoc DOI:
Last Modified:02 Aug 2021 15:08
Deposited On:20 Jul 2011 13:07

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