Pierron, Julien and Malan, Christophe and Creus, Marc and Gradinaru, Julieta and Hafner, Ines and Ivanova, Anita and Sardo, Alessia and Ward, Thomas R.. (2008) Artificial metalloenzymes for asymmetric allylic alkylation on the basis of the biotin-avidin technology. Angewandte Chemie International Edition, 47 (4). pp. 701-705.
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Official URL: http://edoc.unibas.ch/dok/A5254470
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Abstract
Palladium in the active site: The incorporation of a biotinylated palladium diphosphine within streptavidin yielded an artificial metalloenzyme for the title reaction (see scheme). Chemogenetic optimization of the catalyst by the introduction of a spacer (red star) between biotin (green triangle) and palladium and saturation mutagenesis at position S112X afforded both R- and S-selective artificial asymmetric allylic alkylases.
| Faculties and Departments: | 05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward) |
|---|---|
| UniBasel Contributors: | Ward, Thomas R. R. |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Wiley |
| ISSN: | 1433-7851 |
| e-ISSN: | 1521-3773 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: | |
| Last Modified: | 24 Apr 2017 12:31 |
| Deposited On: | 22 Mar 2012 14:16 |
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