Schumacher, Andreas and Jessen, Henning J. and Shaw, Trawis and Pfaltz, Andreas and Gademann, Karl. (2011) A Unified Approach for the Stereoselective Total Synthesis of Pyridone Alkaloids and Their Neuritogenic Activity. Angewandte Chemie International Edition, 50 (18). pp. 4222-4226.
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Official URL: http://edoc.unibas.ch/dok/A5849081
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Abstract
Unus pro omnibus: The development of compounds inducing neurite outgrowth might constitute a valuable approach for the non-invasive medical treatment of neurodegenerative diseases. With the aid of a bifunctional building block, the total syntheses of a group of pyridone polyenes originally produced by entomopathogenic fungi was achieved (see picture). All of these natural products displayed neuritogenic activity in the PC-12 cell line.
| Faculties and Departments: | 05 Faculty of Science > Departement Chemie > Former Organization Units Chemistry > Organische Chemie (Gademann) 05 Faculty of Science > Departement Chemie > Former Organization Units Chemistry > Synthetische organische Chemie (Pfaltz) |
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| UniBasel Contributors: | Gademann, Karl and Pfaltz, Andreas |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Wiley |
| ISSN: | 1433-7851 |
| e-ISSN: | 1521-3773 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 10 Apr 2017 09:52 |
| Deposited On: | 14 Sep 2012 07:02 |
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