Wang, Xiaofang and Zhao, Qingjie and Vargas, Mireille and Dong, Yuxiang and Sriraghavan, Kamaraj and Keiser, Jennifer and Vennerstrom, Jonathan L.. (2011) The activity of dispiro peroxides against Fasciola hepatica. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 21, H. 18. pp. 5320-5330.
Full text not available from this repository.
Official URL: http://edoc.unibas.ch/dok/A6002366
Downloads: Statistics Overview
Abstract
Dispiro 1,2,4-trioxanes and 1,2,4,5-tetraoxanes had superior efficacy against Fasciola hepatica than the corresponding ozonides (1,2,4-trioxolanes). For highest efficacy, spiroadamantane and carboxymethyl substructures were required. Three compounds completely cured F. hepatica-infected mice at single oral doses of 50mg/kg and two were partially curative at single doses of 25mg/kg
| Faculties and Departments: | 03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Klinische Pharmakologie 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Klinische Pharmakologie 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Helminth Drug Development (Keiser) |
|---|---|
| UniBasel Contributors: | Keiser, Jennifer |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Pergamon |
| ISSN: | 0960-894X |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Related URLs: | |
| Identification Number: |
|
| Last Modified: | 08 Nov 2012 16:22 |
| Deposited On: | 08 Nov 2012 16:12 |
Repository Staff Only: item control page