Pfefferle, P. I. and Buchele, G. and Blumer, N. and Roponen, M. and Ege, M. J. and Krauss-Etschmann S., and Genuneit, J. and Hyvarinen, A. and Hirvonen, M. R. and Lauener, R. and Pekkanen, J. and Riedler, J. and Dalphin, J. C. and Brunekeef, B. and Braun-Fahrländer C., and von Mutius E., and Renz, H.. (2010) Cord blood cytokines are modulated by maternal farming activities and consumption of farm dairy products during pregnancy: the PASTURE Study. Journal of allergy and clinical immunology, 125 (1). pp. 108-115.
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Official URL: http://edoc.unibas.ch/dok/A5842854
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Abstract
BACKGROUND: Traditional farming represents a unique model situation to investigate the relationship of early-life farm-related exposure and allergy protection. OBJECTIVES: To investigate associations between maternal farm exposures and cytokine production in cord blood (CB) mononuclear cells in a prospective multinational birth cohort of 299 farm and 326 nonfarm children and their families. METHODS: Supernatants from phorbol 12-myristate 13-acetate/ionomycin-stimulated CB mononuclear cells were assessed for the production of IFN-gamma, TNF-alpha, IL-5, IL-10, and IL-12. RESULTS: Significantly higher levels of IFN-gamma and TNF-alpha in farm compared with nonfarm children were found, whereas IL-5, IL-10, and IL-12 levels did not differ between study groups. Maternal contact with different farm animal species and barns and consumption of farm-produced butter during pregnancy enhanced the production of proinflammatory CB cytokines, whereas maternal consumption of farm-produced yogurt resulted in significant lower levels of IFN-gamma and TNF-alpha in umbilical blood. CONCLUSION: Maternal exposure to farming activities and farm dairy products during pregnancy modulated cytokine production patterns of offspring at birth
| Faculties and Departments: | 03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Environmental Exposures and Health Systems Research > Physical Hazards and Health (Röösli) |
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| UniBasel Contributors: | Braun-Fahrländer, Charlotte |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Mosby |
| ISSN: | 0091-6749 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Identification Number: |
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| Last Modified: | 27 Oct 2017 09:39 |
| Deposited On: | 07 Dec 2012 12:58 |
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