Tishinov, Kiril and Schmidt, Kristina and Häussinger, Daniel and Gillingham, Dennis. (2012) Structure-selective catalytic alkylation of DNA and RNA. Angewandte Chemie International Edition, 51 (48). pp. 12000-12004.
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Abstract
A variety of nucleic acids can be catalytically alkylated with rhodium-carbenoids generated from diazo compounds in aqueous buffer through an NH insertion process (see scheme; MES=2-(N-morpholino)ethanesulfonic acid). The method specifically targets unpaired bases such as those present in single strands, turn regions, and overhangs while leaving double-stranded sequences untouched.
| Faculties and Departments: | 05 Faculty of Science > Departement Chemie > Chemie > Organische Chemie (Gillingham) |
|---|---|
| UniBasel Contributors: | Gillingham, Dennis and Tishinov, Kiril and Häussinger, Daniel |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Wiley |
| ISSN: | 1433-7851 |
| e-ISSN: | 1521-3773 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Language: | English |
| Identification Number: | |
| edoc DOI: | |
| Last Modified: | 16 Feb 2017 10:41 |
| Deposited On: | 01 Feb 2013 08:44 |
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