Isler, Silvia G.. SPARC-like 1 (SPARCL1), a gene downregulated in non-small cell lung cancer. 2004, Doctoral Thesis, University of Basel, Faculty of Science.
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Official URL: http://edoc.unibas.ch/diss/DissB_6781
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Abstract
The aim of this thesis was to find out whether SPARCL1 is a tumor suppressor gene with mutation or deletion in its genomic region and to reveal the mechanism leading to its downregulation. Furthermore, we wanted to see whether SC1 mRNA is also downregulated in mouse lung tumors. Using a new anti-SPARCL1/SC1 antibody we planned to investigate the protein expression pattern in different healthy tissues as well as in tumorous tissues of humans and mice.
| Advisors: | Ludwig, Christian |
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| Committee Members: | Affolter, Markus and Chiquet-Ehrismann, Ruth |
| Faculties and Departments: | 03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) |
| UniBasel Contributors: | Affolter, Markus |
| Item Type: | Thesis |
| Thesis Subtype: | Doctoral Thesis |
| Thesis no: | 6781 |
| Thesis status: | Complete |
| Number of Pages: | 75 |
| Language: | English |
| Identification Number: |
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| edoc DOI: | |
| Last Modified: | 02 Aug 2021 15:04 |
| Deposited On: | 13 Feb 2009 15:10 |
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