Wicki, Andreas and Rochlitz, Christoph and Orleth, Annette and Ritschard, Reto and Albrecht, Imke and Herrmann, Richard and Christofori, Gerhard and Mamot, Christoph. (2012) Targeting tumor-associated endothelial cells: anti-VEGFR2 immunoliposomes mediate tumor vessel disruption and inhibit tumor growth. Clinical cancer research, Vol. 18, no. 18. pp. 454-464.
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Official URL: http://edoc.unibas.ch/dok/A6003365
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Abstract
Angiogenesis is a key process in tumor progression. By binding VEGF, VEGF receptor-2 (VEGFR2) is a main signaling transducer in tumor-associated angiogenesis. Accordingly, therapeutic approaches against the VEGF/VEGFR2 signaling axis have been designed. However, an efficient and specific chemotherapeutic targeting of tumor-associated endothelial cells has not yet been achieved.
| Faculties and Departments: | 03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Onkologie (Herrmann) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Onkologie (Herrmann) 03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Cancer Immunology and Biology (Zippelius/Rochlitz) 03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Tumor Biology (Christofori) |
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| UniBasel Contributors: | Mamot, Christoph and Christofori, Gerhard M. and Rochlitz, Christoph |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | American Association for Cancer Research |
| ISSN: | 1078-0432 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Last Modified: | 10 Apr 2015 09:14 |
| Deposited On: | 26 Apr 2013 07:01 |
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