Wymann, Matthias. (2012) PI3Ks-drug targets in inflammation and cancer. Subcellular biochemistry, Vol. 58. pp. 111-181.
Full text not available from this repository.
Official URL: http://edoc.unibas.ch/dok/A6005996
Downloads: Statistics Overview
Abstract
Phosphoinositide 3-kinases (PI3Ks) control cell growth, proliferation, cell survival, metabolic activity, vesicular trafficking, degranulation, and migration. Through these processes, PI3Ks modulate vital physiology. When over-activated in disease, PI3K promotes tumor growth, angiogenesis, metastasis or excessive immune cell activation in inflammation, allergy and autoimmunity. This chapter will introduce molecular activation and signaling of PI3Ks, and connections to target of rapamycin (TOR) and PI3K-related protein kinases (PIKKs). The focus will be on class I PI3Ks, and extend into current developments to exploit mechanistic knowledge for therapy.
| Faculties and Departments: | 03 Faculty of Medicine > Departement Biomedizin > Division of Biochemistry and Genetics > Cancer- and Immunobiology (Wymann) |
|---|---|
| UniBasel Contributors: | Wymann, Matthias P. |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Springer |
| ISSN: | 0306-0225 |
| Note: | Also published in: Phosphoinositides I: Enzymes of Synthesis and Degradation. - Dordrecht : Springer, 2012. - S. 111-181 -- Publication type according to Uni Basel Research Database: Journal article |
| Related URLs: | |
| Identification Number: |
|
| Last Modified: | 10 Apr 2015 09:13 |
| Deposited On: | 26 Apr 2013 07:01 |
Repository Staff Only: item control page