Padavattan, S. and Schmidt, M. and Hoffman, D. R. and Markovic-Housley, Z.. (2008) Crystal structure of the major allergen from fire ant venom, Sol i 3. Journal of molecular biology, Vol. 383, H. 1. pp. 178-185.
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Official URL: http://edoc.unibas.ch/dok/A5258233
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Abstract
Fire ant venom is an extremely potent allergy-inducing agent containing four major allergens, Sol i 1 to Sol i 4, which are the most frequent cause of hypersensitivity reactions to hymenoptera in the southern USA. The crystal structure of recombinant (Baculovirus) major fire ant allergen Sol i 3 has been determined to a resolution of 3.1 A by the method of molecular replacement. The secondary-structure elements of Sol i 3 are arranged in an alpha-beta-alpha sandwich fold consisting of a central antiparallel beta-sheet surrounded on both sides by alpha helices. The overall structure is very similar to that of the homologous wasp venom allergen Ves v 5 with major differences occurring in the solvent-exposed loop regions that contain amino acid insertions. Consequently, the limited conservation of surface chemical properties and topology between Sol i 3 and Ves v 5 may explain the observed lack of relevant cross-reactivity. It is concluded that Sol i 3 recognizes immunoglobulin E antibodies with a distinct set of its own epitopes, which are different from those of Ves v 5. Indeed, the molecular area in Sol i 3 covered by non-conserved residues is large enough to accommodate four unique Sol i 3 epitopes.
Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Schirmer) |
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UniBasel Contributors: | Schirmer, Tilman and Housley-Markovic, Zora |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Elsevier |
ISSN: | 0022-2836 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
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Last Modified: | 14 Sep 2012 06:50 |
Deposited On: | 22 Mar 2012 13:20 |
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