Niehl, Annette and Amari, Khalid and Heinlein, Manfred. (2013) CDC48 function during TMV infection: Regulation of virus movement and replication by degradation? Plant signaling & behavior, Vol. 8 , e22865.
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Official URL: http://edoc.unibas.ch/dok/A6146278
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Abstract
Cell-division-cycle protein 48 (CDC48) is an essential, conserved ATP-driven chaperone in eukaryotic cells, which functions in diverse cellular processes including the targeting of misfolded and aggregated proteins for degradation via proteasomal and aggresomal-autophagic pathways. We recently demonstrated that plant CDC48 localizes to and interacts with Tobacco mosaic virus (TMV) movement protein (MP) in ER-associated viral protein inclusions. Our data suggest that CDC48 participates in the clearance of these viral protein inclusions in an ER-assisted protein degradation (ERAD)-like mechanism. As TMV MP-inclusions formed at late infection stages resemble aggresomes, we here propose that TMV MP enters both, ERAD-like and aggresomal pathways in its host cells and that CDC48 coordinates these processes. Moreover, as viruses often exploit host pathways for replication and spread, we propose a model in which CDC48 functions in the degradation pathway of overaccumulating viral protein and also actively participates in the regulation of TMV replication and cell-to-cell movement.
Faculties and Departments: | 05 Faculty of Science > Departement Umweltwissenschaften > Integrative Biologie |
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UniBasel Contributors: | Heinlein, Manfred and Amari, Khalid and Niehl, Annette |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Landes Bioscience |
Note: | Publication type according to Uni Basel Research Database: Journal article |
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Last Modified: | 19 Jul 2013 07:44 |
Deposited On: | 19 Jul 2013 07:42 |
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