Scherr, N. and Röltgen, K. and Witschel, M. and Pluschke, G.. (2012) Screening of antifungal azole drugs and agrochemicals with an adapted Alamar Blue-based assay demonstrates antibacterial activity of Croconazole against Mycobacterium ulcerans. Antimicrobial agents and chemotherapy, Vol. 56, H. 12. pp. 6410-6413.
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Official URL: http://edoc.unibas.ch/dok/A6094358
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Abstract
An Alamar Blue-based growth inhibition assay has been adapted for the thermosensitive and slow growing pathogen Mycobacterium ulcerans (M. ulcerans). The standardized test procedure enables medium-throughput screening of pre-selected compound libraries. Testing of a set of 48 azoles with known antifungal activity led to the identification of an imidazole antifungal displaying an inhibitory dose (ID) of 9 muM for M. ulcerans
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Molecular Immunology (Pluschke) |
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| UniBasel Contributors: | Pluschke, Gerd |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | American Society for Microbiology |
| ISSN: | 0066-4804 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Related URLs: | |
| Identification Number: |
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| Last Modified: | 19 Jul 2013 07:44 |
| Deposited On: | 19 Jul 2013 07:42 |
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