Schomaker, Michael and Egger, Matthias and Maskew, Mhairi and Garone, Daniela and Prozesky, Hans and Hoffmann, Christopher J. and Boulle, Andrew and Fenner, Lukas. (2013) Immune recovery after starting ART in HIV-infected patients presenting and not presenting with Tuberculosis in south Africa. JAIDS : journal of acquired immune deficiency syndromes : official publication of the International Retrovirology Association, Vol. 63, H. 1. pp. 142-145.
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Official URL: http://edoc.unibas.ch/dok/A6124626
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Abstract
We studied the immune response after starting antiretroviral treatment (ART) in 15,646 HIV-infected patients with or without tuberculosis (TB) at presentation in 3 ART programs in South Africa between 2003 and 2010. Patients presenting with TB had similar increases in CD4 cells compared with all other patients (adjusted difference 4.9 cells/µL per 6 months, 95% confidence interval: 0.2 to 9.7). Younger age, advanced clinical stage, female sex, and lower CD4 cell count at ART start were all associated with steeper CD4 slopes. In South Africa, HIV-infected patients presenting with TB experience immune recovery after starting ART that is no worse than in other patients.
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Tuberculosis Ecology and Evolution Unit (Gagneux) |
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| UniBasel Contributors: | Fenner, Lukas |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Lippincott Williams & Wilkins |
| ISSN: | 1525-4135 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Last Modified: | 16 Aug 2013 07:34 |
| Deposited On: | 16 Aug 2013 07:30 |
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