Christofori, Gerhard. (2011) Metastatic colon cancer cells negotiate the intravasation notch. Cancer cell, Vol. 19, H. 1. pp. 6-8.
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Official URL: http://edoc.unibas.ch/dok/A6006418
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Abstract
In this issue of Cancer Cell, Sonoshita et al. report that Aes/Grg5 prevents metastasis of colorectal cancer cells by sequestering and inactivating Notch transcriptional effectors in distinct nuclear foci. Loss of Aes/Grg5 in invasive cancer cells where Notch is activated by stroma-expressed ligands promotes invasion, transendothelial migration, intravasation, and metastasis.
| Faculties and Departments: | 03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Tumor Biology (Christofori) |
|---|---|
| UniBasel Contributors: | Christofori, Gerhard M. |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Cell Press |
| ISSN: | 1535-6108 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Last Modified: | 10 Apr 2015 09:13 |
| Deposited On: | 13 Sep 2013 07:49 |
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