Hoecker, Johannes and Gademann, Karl. (2013) Enantioselective Total Syntheses and Absolute Configuration of JBIR-02 and Mer-A2026B. Organic letters, Vol. 15, H. 3 , S. 670–673.
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Official URL: http://edoc.unibas.ch/dok/A6194503
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Abstract
The first total syntheses of the piericidin related natural products Mer-A2026B and JBIR-02 are reported. Key features of the synthetic approach involve an Ir-catalyzed one-pot C-H activation/oxidation procedure for the preparation of the hydroxypyridine, a vinylogous Mukaiyama aldol reaction, and a final Negishi cross-coupling of an advanced pyridine derivative with an allylic side chain precursor. In addition, the absolute configuration of Mer-A2026B (9R,10R) and JBIR-02 (9R,10R) was established.
| Faculties and Departments: | 05 Faculty of Science > Departement Chemie > Former Organization Units Chemistry > Organische Chemie (Gademann) |
|---|---|
| UniBasel Contributors: | Gademann, Karl and Hoecker, Johannes David |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | American Chemical Society |
| ISSN: | 1523-7060 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Last Modified: | 06 Dec 2013 09:35 |
| Deposited On: | 06 Dec 2013 09:35 |
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