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Natural channel protein inserts and functions in a completely artificial, solid-supported bilayer membrane

Zhang, Xiaoyan and Fu, Wangyang and Palivan, Cornelia G. and Meier, Wolfgang. (2013) Natural channel protein inserts and functions in a completely artificial, solid-supported bilayer membrane. Scientific Reports, 3. p. 2196.

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Official URL: http://edoc.unibas.ch/dok/A6212308

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Abstract

Reconstitution of membrane proteins in artificial membrane systems creates a platform for exploring their potential for pharmacological or biotechnological applications. Previously, we demonstrated amphiphilic block copolymers as promising building blocks for artificial membranes with long-term stability and tailorable structural parameters. However, the insertion of membrane proteins has not previously been realized in a large-area, stable, and solid-supported artificial membrane. Here, we show the first, preliminary model of a channel membrane protein that is functionally incorporated in a completely artificial polymer, tethered, solid-supported bilayer membrane (TSSBM). Unprecedented ionic transport characteristics that differ from previous results on protein insertion into planar, free-standing membranes, are identified. Our findings mark a change in understanding protein insertion and ion flow within natural channel proteins when inserted in an artificial TSSBM, thus holding great potential for numerous applications such as drug screening, trace analyzing, and biosensing.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Former Organization Units Chemistry > Makromolekulare Chemie (Meier)
UniBasel Contributors:Palivan, Cornelia G
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
e-ISSN:2045-2322
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:12 Oct 2017 09:36
Deposited On:31 Jan 2014 09:50

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