Waldhauser, K. M. and Brecht, K. and Hebeisen, S. and Ha, H. R. and Konrad, D. and Bur, D. and Krähenbühl, S.. (2008) Interaction with the hERG channel and cytotoxicity of amiodarone and amiodarone analogues. British journal of pharmacology, Vol. 155, no. 4. pp. 585-595.
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Official URL: http://edoc.unibas.ch/dok/A6004840
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Abstract
Amiodarone (2-n-butyl-3-[3,5 diiodo-4-diethylaminoethoxybenzoyl]-benzofuran, B2-O-CH(2)CH(2)-N-diethyl) is an effective class III antiarrhythmic drug demonstrating potentially life-threatening organ toxicity. The principal aim of the study was to find amiodarone analogues that retained human ether-a-go-go-related protein (hERG) channel inhibition but with reduced cytotoxicity.
| Faculties and Departments: | 03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Klinische Pharmakologie > Klinische Pharmakologie (Krähenbühl) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Klinische Pharmakologie > Klinische Pharmakologie (Krähenbühl) |
|---|---|
| UniBasel Contributors: | Krähenbühl, Stephan |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Nature Publishing Group |
| ISSN: | 0007-1188 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Last Modified: | 25 Apr 2014 08:01 |
| Deposited On: | 25 Apr 2014 08:01 |
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