Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts : results from the ESCAPE and TRANSPHORM projects

Wang, Meng and Beelen, Rob and Stafoggia, Massimo and Raaschou-Nielsen, Ole and Andersen, Zorana Jovanovic and Hoffmann, Barbara and Fischer, Paul and Houthuijs, Danny and Nieuwenhuijsen, Mark and Weinmayr, Gudrun and Vineis, Paolo and Xun, Wei W. and Dimakopoulou, Konstantina and Samoli, Evangelia and Laatikainen, Tiina and Lanki, Timo and Turunen, Anu W. and Oftedal, Bente and Schwarze, Per and Aamodt, Geir and Penell, Johanna and De Faire, Ulf and Korek, Michal and Leander, Karin and Pershagen, Göran and Pedersen, Nancy L. and Ostenson, Claes-Göran and Fratiglioni, Laura and Eriksen, Kirsten Thorup and Sørensen, Mette and Tjønneland, Anne and Bueno-de-Mesquita, Bas and Eeftens, Marloes and Bots, Michiel L. and Meliefste, Kees and Krämer, Ursula and Heinrich, Joachim and Sugiri, Dorothea and Key, Timothy and de Hoogh, Kees and Wolf, Kathrin and Peters, Annette and Cyrys, Josef and Jaensch, Andrea and Concin, Hans and Nagel, Gabriele and Tsai, Ming-Yi and Phuleria, Harish and Ineichen, Alex and Künzli, Nino and Probst-Hensch, Nicole and Schaffner, Emmanuel and Vilier, Alice and Clavel-Chapelon, Françoise and Declerq, Christophe and Ricceri, Fulvio and Sacerdote, Carlotta and Marcon, Alessandro and Galassi, Claudia and Migliore, Enrica and Ranzi, Andrea and Cesaroni, Giulia and Badaloni, Chiara and Forastiere, Francesco and Katsoulis, Michail and Trichopoulou, Antonia and Keuken, Menno and Jedynska, Aleksandra and Kooter, Ingeborg M. and Kukkonen, Jaakko and Sokhi, Ranjeet S. and Brunekreef, Bert and Katsouyanni, Klea and Hoek, Gerard. (2014) Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts : results from the ESCAPE and TRANSPHORM projects. Environment international : a journal of environmental science, risk and health, 66. pp. 97-106.

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Official URL: http://edoc.unibas.ch/dok/A6243556

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Abstract

Associations between long-term exposure to ambient particulate matter (PM) and cardiovascular (CVD) mortality have been widely recognized. However, health effects of long-term exposure to constituents of PM on total CVD mortality have been explored in a single study only.; The aim of this study was to examine the association of PM composition with cardiovascular mortality.; We used data from 19 European ongoing cohorts within the framework of the ESCAPE (European Study of Cohorts for Air Pollution Effects) and TRANSPHORM (Transport related Air Pollution and Health impacts - Integrated Methodologies for Assessing Particulate Matter) projects. Residential annual average exposure to elemental constituents within particle matter smaller than 2.5 and 10μm (PM2.5 and PM10) was estimated using Land Use Regression models. Eight elements representing major sources were selected a priori (copper, iron, potassium, nickel, sulfur, silicon, vanadium and zinc). Cohort-specific analyses were conducted using Cox proportional hazards models with a standardized protocol. Random-effects meta-analysis was used to calculate combined effect estimates.; The total population consisted of 322,291 participants, with 9545 CVD deaths. We found no statistically significant associations between any of the elemental constituents in PM2.5 or PM10 and CVD mortality in the pooled analysis. Most of the hazard ratios (HRs) were close to unity, e.g. for PM10 Fe the combined HR was 0.96 (0.84-1.09). Elevated combined HRs were found for PM2.5 Si (1.17, 95% CI: 0.93-1.47), and S in PM2.5 (1.08, 95% CI: 0.95-1.22) and PM10 (1.09, 95% CI: 0.90-1.32).; In a joint analysis of 19 European cohorts, we found no statistically significant association between long-term exposure to 8 elemental constituents of particles and total cardiovascular mortality.

Faculties and Departments:	03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Air Pollution and Health (Künzli) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Former Units within Swiss TPH > Air Pollution and Health (Künzli) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Exposome Science (Probst-Hensch) 03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Exposome Science (Probst-Hensch) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Former Units within Swiss TPH > Exposure Science (Tsai)
UniBasel Contributors:	Ineichen, Alex and Künzli, Nino and Probst Hensch, Nicole
Item Type:	Article, refereed
Article Subtype:	Research Article
Publisher:	Elsevier
ISSN:	0160-4120
Note:	Publication type according to Uni Basel Research Database: Journal article
Related URLs:	Document Document
Identification Number:	pmid: 24561271 doi: 10.1016/j.envint.2014.01.026
Last Modified:	27 Oct 2017 11:55
Deposited On:	18 Jul 2014 09:10

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