Air pollution and nonmalignant respiratory mortality in 16 cohorts within the ESCAPE project

Dimakopoulou, Konstantina and Samoli, Evangelia and Beelen, Rob and Stafoggia, Massimo and Andersen, Zorana Jovanovic and Hoffmann, Barbara and Fischer, Paul and Nieuwenhuijsen, Mark and Vineis, Paolo and Xun, Wei and Hoek, Gerard and Raaschou-Nielsen, Ole and Oudin, Anna and Forsberg, Bertil and Modig, Lars and Jousilahti, Pekka and Lanki, Timo and Turunen, Anu and Oftedal, Bente and Nafstad, Per and Schwarze, Per E. and Penell, Johanna and Fratiglioni, Laura and Andersson, Niklas and Pedersen, Nancy and Korek, Michal and De Faire, Ulf and Eriksen, Kirsten Thorup and Tjønneland, Anne and Becker, Thomas and Wang, Meng and Bueno-de-Mesquita, Bas and Tsai, Ming-Yi and Eeftens, Marloes and Peeters, Petra H. and Meliefste, Kees and Marcon, Alessandro and Krämer, Ursula and Kuhlbusch, Thomas A. J. and Vossoughi, Mohammad and Key, Timothy and de Hoogh, Kees and Hampel, Regina and Peters, Annette and Heinrich, Joachim and Weinmayr, Gudrun and Concin, Hans and Nagel, Gabriele and Ineichen, Alex and Jacquemin, Bénédicte and Stempfelet, Morgane and Vilier, Alice and Ricceri, Fulvio and Sacerdote, Carlotta and Pedeli, Xanthi and Katsoulis, Michalis and Trichopoulou, Antonia and Brunekreef, Bert and Katsouyanni, Klea. (2014) Air pollution and nonmalignant respiratory mortality in 16 cohorts within the ESCAPE project. American journal of respiratory and critical care medicine : an official journal of the American Thoracic Society, Vol. 189, H. 6. pp. 684-696.

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Official URL: http://edoc.unibas.ch/dok/A6243519

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Abstract

Rationale: Prospective cohort studies have shown that chronic exposure to particulate matter and traffic-related air pollution is associated with reduced survival. However, the effects on nonmalignant respiratory mortality are less studied, and the data reported are less consistent. Objectives: We have investigated the relationship of long-term exposure to air pollution and nonmalignant respiratory mortality in 16 cohorts with individual level data within the multicenter European Study of Cohorts for Air Pollution Effects (ESCAPE). Methods: Data from 16 ongoing cohort studies from Europe were used. The total number of subjects was 307,553. There were 1,559 respiratory deaths during follow-up. Measurements and Main Results: Air pollution exposure was estimated by land use regression models at the baseline residential addresses of study participants and traffic-proximity variables were derived from geographical databases following a standardized procedure within the ESCAPE study. Cohort-specific hazard ratios obtained by Cox proportional hazard models from standardized individual cohort analyses were combined using metaanalyses. We found no significant associations between air pollution exposure and nonmalignant respiratory mortality. Most hazard ratios were slightly below unity, with the exception of the traffic-proximity indicators. Conclusions: In this study of 16 cohorts, there was no association between air pollution exposure and nonmalignant respiratory mortality.

Faculties and Departments:	09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Former Units within Swiss TPH > Exposure Science (Tsai)
UniBasel Contributors:	Tsai, Ming and Eeftens, Marloes and Ineichen, Alex
Item Type:	Article, refereed
Article Subtype:	Research Article
Publisher:	HighWire Press
ISSN:	0003-0805
Note:	Publication type according to Uni Basel Research Database: Journal article
Related URLs:	Document Document
Identification Number:	pmid: 24521254 doi: 10.1164/rccm.201310-1777OC
Last Modified:	15 Aug 2014 07:16
Deposited On:	15 Aug 2014 07:16

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