Omolo, J. J. and Maharaj, V. and Naidoo, D. and Klimkait, T. and Malebo, H. M. and Mtullu, S. and Lyaruu, H. V. M. and de Koning, C. B.. (2012) Bioassay-guided investigation of the Tanzanian plant Pyrenacantha kaurabassana for potential anti-HIV-active compounds. Journal of natural products, Vol. 75, H. 10. pp. 1712-1716.
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Official URL: http://edoc.unibas.ch/dok/A6338393
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Abstract
Two new anti-HIV xanthones, 6,7,11-trihydroxy-10-methoxy-9-(7-methoxy-3-methyl-1-oxoisochroman-5-yl)-2-methyl- 12-oxo-12H-benzo[b]xanthene-4-carboxylic acid (1) and 6,7-dihydroxy-10,11-dimethoxy-9- (7-methoxy-3-methyl-1-oxoisochroman-5-yl)-2-methyl-12-oxo-12H-benzo [b]xanthene-4-carboxylic acid (2), and a new hexadecahydrochrysen-3-ol (3) were isolated from the tubers of Pyrenacantha kaurabassana. Compounds 1 and 2 showed moderate anti-HIV activity when tested in the deCIPhR assay on HIV virus type NL4-3, with IC50 values of 21 and 2 mu g/mL, respectively.
| Faculties and Departments: | 03 Faculty of Medicine > Departement Biomedizin > Division of Medical Microbiology > Molecular Virology (Klimkait) |
|---|---|
| UniBasel Contributors: | Klimkait, Thomas |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | American Society of Pharmacognosy |
| ISSN: | 0163-3864 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Last Modified: | 08 May 2015 08:45 |
| Deposited On: | 08 May 2015 08:45 |
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