Wicki, Andreas and Witzigmann, Dominik and Balasubramanian, Vimalkumar and Huwyler, Jörg. (2015) Nanomedicine in cancer therapy : challenges, opportunities, and clinical applications. Journal of controlled release, 200. pp. 138-157.
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Official URL: http://edoc.unibas.ch/dok/A6381807
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Abstract
Cancer is a leading cause of death worldwide. Currently available therapies are inadequate and spur demand for improved technologies. Rapid growth in nanotechnology towards the development of nanomedicine products holds great promise to improve therapeutic strategies against cancer. Nanomedicine products represent an opportunity to achieve sophisticated targeting strategies and multi-functionality. They can improve the pharmacokinetic and pharmacodynamic profiles of conventional therapeutics and may thus optimize the efficacy of existing anti-cancer compounds. In this review, we discuss state-of-the-art nanoparticles and targeted systems that have been investigated in clinical studies. We emphasize the challenges faced in using nanomedicine products and translating them from a preclinical level to the clinical setting. Additionally, we cover aspects of nanocarrier engineering that may open up new opportunities for nanomedicine products in the clinic.
| Faculties and Departments: | 05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmaceutical Technology (Huwyler) |
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| UniBasel Contributors: | Huwyler, Jörg |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Elsevier |
| ISSN: | 0168-3659 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Last Modified: | 11 Aug 2016 06:08 |
| Deposited On: | 05 Jun 2015 08:53 |
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