Spinas, G. A. and Bloesch, D. and Kaufmann, M. T. and Keller, U. and Dayer, J. M.. (1990) Induction of plasma inhibitors of interleukin 1 and TNF-alpha activity by endotoxin administration to normal humans. American journal of physiology : AJP, Vol. 259, H. 5 Pt. 2 , R993-R997.
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Official URL: http://edoc.unibas.ch/dok/A6419889
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Abstract
Several naturally occurring inhibitors of interleukin 1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) have been demonstrated both in serum and urine of febrile patients. These factors are considered to be part of a regulatory system counteracting potential deleterious effects of the cytokines. We have assayed plasma samples of volunteers who received a bolus intravenous injection of either 4 ng/kg body wt of Escherichia coli endotoxin (n = 6) or 0.9% saline (n = 4) for the presence of IL-1 and TNF-alpha inhibitory activity. Plasma obtained 3 h after endotoxin injection inhibited IL-1-induced PGE2 release from fibroblasts by 57% (P less than 0.001 vs. baseline and saline controls, respectively). Maximal IL-1 inhibitory capacity coincided with fever and tended to disappear with declining body temperature. Normal plasma was found to inhibit TNF-alpha-induced PGE2 release by 20-35%. This inhibitory effect increased to 50-60% in plasma obtained during endotoxinemia. Maximal TNF-alpha inhibitory capacity became detectable when circulating TNF-alpha levels peaked at 120 min after the injection of endotoxin. Our data demonstrate that both IL-1 and TNF-alpha inhibitory activity can be induced experimentally by intravenous endotoxin administration to humans and that their appearance coincides with fever and circulating TNF-alpha levels.
Faculties and Departments: | 03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Metabolism (Keller/Müller) 03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Klinische Endokrinologie (Keller) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Klinische Endokrinologie (Keller) |
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UniBasel Contributors: | Keller, Ulrich O. |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | American Physiological Society |
ISSN: | 0002-9513 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Last Modified: | 04 Sep 2015 14:32 |
Deposited On: | 04 Sep 2015 14:32 |
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