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Rootletin organizes the ciliary rootlet to achieve neuron sensory function in Drosophila

Chen, Jieyan V. and Kao, Ling-Rong and Jana, Swadhin C. and Sivan-Loukianova, Elena and Mendonça, Susana and Cabrera, Oscar A. and Singh, Priyanka and Cabernard, Clemens and Eberl, Daniel F. and Bettencourt-Dias, Monica and Megraw, Timothy L.. (2015) Rootletin organizes the ciliary rootlet to achieve neuron sensory function in Drosophila. Journal of cell biology, 211 (2). pp. 435-453.

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Official URL: http://edoc.unibas.ch/39615/

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Abstract

Cilia are essential for cell signaling and sensory perception. In many cell types, a cytoskeletal structure called the ciliary rootlet links the cilium to the cell body. Previous studies indicated that rootlets support the long-term stability of some cilia. Here we report that Drosophila melanogaster Rootletin (Root), the sole orthologue of the mammalian paralogs Rootletin and C-Nap1, assembles into rootlets of diverse lengths among sensory neuron subtypes. Root mutant neurons lack rootlets and have dramatically impaired sensory function, resulting in behavior defects associated with mechanosensation and chemosensation. Root is required for cohesion of basal bodies, but the cilium structure appears normal in Root mutant neurons. We show, however, that normal rootlet assembly requires centrioles. The N terminus of Root contains a conserved domain and is essential for Root function in vivo. Ectopically expressed Root resides at the base of mother centrioles in spermatocytes and localizes asymmetrically to mother centrosomes in neuroblasts, both requiring Bld10, a basal body protein with varied functions.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Growth and Development (Cabernard)
UniBasel Contributors:Cabernard, Clemens
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Rockefeller University Press
ISSN:0021-9525
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:30 Jun 2016 10:59
Deposited On:18 May 2016 08:17

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