Einfalt, Tomaz and Goers, Roland and Dinu, Ionel Adrian and Najer, Adrian and Spulber, Mariana and Onaca-Fischer, Ozana and Palivan, Cornelia G. . (2015) Stimuli-Triggered Activity of Nanoreactors by Biomimetic Engineering Polymer Membranes. Nano Letters, 15 (11). pp. 7596-7603.
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Official URL: http://edoc.unibas.ch/39772/
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Abstract
The development of advanced stimuli-responsive systems for medicine, catalysis, or technology requires compartmentalized reaction spaces with triggered activity. Only very few stimuli-responsive systems preserve the compartment architecture, and none allows a triggered activity in situ. We present here a biomimetic strategy to molecular transmembrane transport by engineering synthetic membranes equipped with channel proteins so that they are stimuli-responsive. Nanoreactors with triggered activity were designed by simultaneously encapsulating an enzyme inside polymer compartments, and inserting protein “gates” in the membrane. The outer membrane protein F (OmpF) porin was chemically modified with a pH-responsive molecular cap to serve as “gate” producing pH-driven molecular flow through the membrane and control the in situ enzymatic activity. This strategy provides complex reaction spaces necessary in “smart” medicine and for biomimetic engineering of artificial cells.
Faculties and Departments: | 05 Faculty of Science > Departement Chemie > Chemie > Physikalische Chemie (Palivan) |
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UniBasel Contributors: | Palivan, Cornelia G |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | American Chemical Society |
ISSN: | 1530-6984 |
e-ISSN: | 1530-6992 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Identification Number: | |
Last Modified: | 14 Jun 2017 07:03 |
Deposited On: | 14 Jun 2017 07:03 |
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