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Computational dissection of human episodic memory reveals mental process-specific genetic profiles

Luksys, Gediminas and Fastenrath, Matthias and Coynel, David and Freytag, Virginie and Gschwind, Leo and Heck, Angela and Jessen, Frank and Maier, Wolfgang and Milnik, Annette and Riedel-Heller, Steffi G. and Scherer, Martin and Spalek, Klara and Vogler, Christian and Wagner, Michael and Wolfsgruber, Steffen and Papassotiropoulos, Andreas and de Quervain, Dominique J.-F.. (2015) Computational dissection of human episodic memory reveals mental process-specific genetic profiles. Proceedings of the National Academy of Sciences of the United States of America, 112 (35). pp. 4939-4948.

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Official URL: http://edoc.unibas.ch/40063/

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Abstract

Episodic memory performance is the result of distinct mental processes, such as learning, memory maintenance, and emotional modulation of memory strength. Such processes can be effectively dissociated using computational models. Here we performed gene set enrichment analyses of model parameters estimated from the episodic memory performance of 1,765 healthy young adults. We report robust and replicated associations of the amine compound SLC (solute-carrier) transporters gene set with the learning rate, of the collagen formation and transmembrane receptor protein tyrosine kinase activity gene sets with the modulation of memory strength by negative emotional arousal, and of the L1 cell adhesion molecule (L1CAM) interactions gene set with the repetition-based memory improvement. Furthermore, in a large functional MRI sample of 795 subjects we found that the association between L1CAM interactions and memory maintenance revealed large clusters of differences in brain activity in frontal cortical areas. Our findings provide converging evidence that distinct genetic profiles underlie specific mental processes of human episodic memory. They also provide empirical support to previous theoretical and neurobiological studies linking specific neuromodulators to the learning rate and linking neural cell adhesion molecules to memory maintenance. Furthermore, our study suggests additional memory-related genetic pathways, which may contribute to a better understanding of the neurobiology of human memory.
Faculties and Departments:07 Faculty of Psychology
UniBasel Contributors:Milnik, Annette and Luksys, Gediminas and Fastenrath, Matthias and Coynel, David and Freytag, Virginie and Gschwind, Leo and Heck, Angela and Sifalakis, Klara and Vogler, Christian and Papassotiropoulos, Andreas and de Quervain, Dominique J.-F.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:National Academy of Sciences
ISSN:0027-8424
e-ISSN:1091-6490
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:09 Oct 2017 13:01
Deposited On:09 Oct 2017 13:01

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