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Omega-3 fatty acids in the management of autism spectrum disorders: findings from an open-label pilot study in Singapore

Ooi, Y. P. and Weng, S.-J. and Jang, L. Y. and Low, L. and Seah, J. and Teo, S. and Ang, R. P. and Lim, C. G. and Liew, A. and Fung, D. S. and Sung, M.. (2015) Omega-3 fatty acids in the management of autism spectrum disorders: findings from an open-label pilot study in Singapore. European Journal of Clinical Nutrition, 69 (8). pp. 969-971.

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Official URL: http://edoc.unibas.ch/40080/

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Abstract

The goal of this open-label trial was to examine the efficacy and safety of a 12-week omega-3 fatty acids supplementation among children suffering with Autism Spectrum Disorders (ASD). A total of 41 children and adolescents aged 7-18 years (36 boys, 5 girls; mean age = 11.66, s.d. = 3.05) diagnosed with ASD participated in the study. At post-treatment, participants showed significant improvements on all subscales of the Social Responsiveness Scale (P < 0.01) and the Social and Attention Problems syndrome scales of the Child Behavior Checklist (P < 0.05). Blood fatty acid levels were significantly correlated with changes in the core symptoms of ASD. Baseline levels of blood fatty acid levels were also predictive of response to the omega-3 treatment. Omega-3 fatty acids supplementation was well-tolerated and did not cause any serious side effects. Our findings lend some preliminary support for the use of omega-3 fatty acids supplementation in addressing ASD. Future randomized controlled trials of omega-3 fatty acids in ASD with blood fatty acid measurements with a larger sample and longer follow-up period is warranted.
Faculties and Departments:07 Faculty of Psychology
UniBasel Contributors:Ooi, Yoon Phaik
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
ISSN:0954-3007
e-ISSN:1476-5640
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:02 Nov 2017 10:56
Deposited On:02 Nov 2017 10:56

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