Farimani, Mahdi Moridi and Bahadori, Mir Babak and Koulaei, Sheyda Ahmadi and Salehi, Peyman and Ebrahimi, Samad Nejad and Khavasi, Hamid Reza and Hamburger, Matthias. (2015) New ursane triterpenoids from Salvia urmiensis Bunge: absolute configuration and anti-proliferative activity. Fitoterapia, 106. pp. 1-6.
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Abstract
Two new triterpenoids, urmiensolide B (1) and urmiensic acid (2), with rare carbon skeletons together with three known compounds were isolated from the aerial parts of Salvia urmiensis Bunge, an endemic species of Iran. The structures were established by a combination of 1D and 2D NMR, and HRESIMS, and in the case of 2 and 3, their structures were confirmed by single-crystal X-ray analysis. The absolute configuration of 2 was established by electronic circular dichroism (ECD) spectra. The new compounds were evaluated for their anti-proliferative activities against A549 and MCF-7 human cancer cell lines. Compounds 1 and 2 showed IC50 values of 2.8 and 1.6 μM against MCF-7 cells, respectively.
| Faculties and Departments: | 05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Ehemalige Einheiten Pharmazie > Pharmazeutische Biologie (Hamburger) |
|---|---|
| UniBasel Contributors: | Hamburger, Matthias |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Elsevier |
| ISSN: | 0367-326X |
| e-ISSN: | 1873-6971 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: | |
| Last Modified: | 28 Nov 2017 09:42 |
| Deposited On: | 14 Jun 2016 09:08 |
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