Latest Developments in Metalloenzyme Design and Repurposing

In the past decade, artificial metalloenzymes (AMEs) have emerged as attractive alternatives to more traditional homogeneous catalysts and enzymes. This microreview presents a selection of recent achievements in the design of such hybrid catalysts. These include artificial zinc hydrolases and metathesases, the heme-protein repurposing for C–H, N–H, and S–H insertion reactions, novel light-driven redox hybrid catalysts, novel scaffold proteins, and metallocofactor anchoring techniques and metalloenzyme models.