Goncharenko, Kristina and Seebeck, Florian P.. (2016) Conversion of a non-heme iron-dependent sulfoxide synthase into a thiol dioxygenase by a single point mutation. Chemical Communications , 52 (9). pp. 1945-1948.
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Abstract
EgtB from Mycobacterium thermoresistibile catalyzes O2-dependent sulfur-carbon bond formation between the side chains of Nα-trimethyl histidine and γ-glutamyl cysteine as a central step in ergothioneine biosynthesis. A single point mutation converts this enzyme into a γ-glutamyl cysteine dioxygenase with an efficiency that rivals naturally evolved thiol dioxygenases.
Faculties and Departments: | 05 Faculty of Science > Departement Chemie > Chemie > Molecular Bionics (Seebeck) |
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UniBasel Contributors: | Seebeck, Florian Peter |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Royal Society of Chemistry |
ISSN: | 1359-7345 |
e-ISSN: | 1364-548X |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Language: | English |
Identification Number: |
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edoc DOI: | |
Last Modified: | 28 Nov 2016 14:56 |
Deposited On: | 25 Apr 2016 13:07 |
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