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Electroencephalographic features of convulsive epilepsy in Africa : a multicentre study of prevalence, pattern and associated factors

Kariuki, Symon M. and White, Steven and Chengo, Eddie and Wagner, Ryan G. and Ae-Ngibise, Kenneth A. and Kakooza-Mwesige, Angelina and Masanja, Honorati and Ngugi, Anthony K. and Sander, Josemir W. and Neville, Brian G. and Newton, Charles R. and Seeds investigators, . (2016) Electroencephalographic features of convulsive epilepsy in Africa : a multicentre study of prevalence, pattern and associated factors. Clinical neurophysiology, 127 (2). pp. 1099-1107.

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Official URL: http://edoc.unibas.ch/42163/

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Abstract

We investigated the prevalence and pattern of electroencephalographic (EEG) features of epilepsy and the associated factors in Africans with active convulsive epilepsy (ACE).; We characterized electroencephalographic features and determined associated factors in a sample of people with ACE in five African sites. Mixed-effects modified Poisson regression model was used to determine factors associated with abnormal EEGs.; Recordings were performed on 1426 people of whom 751 (53%) had abnormal EEGs, being an adjusted prevalence of 2.7 (95% confidence interval (95% CI), 2.5-2.9) per 1000. 52% of the abnormal EEG had focal features (75% with temporal lobe involvement). The frequency and pattern of changes differed with site. Abnormal EEGs were associated with adverse perinatal events (risk ratio (RR)=1.19 (95% CI, 1.07-1.33)), cognitive impairments (RR=1.50 (95% CI, 1.30-1.73)), use of anti-epileptic drugs (RR=1.25 (95% CI, 1.05-1.49)), focal seizures (RR=1.09 (95% CI, 1.00-1.19)) and seizure frequency (RR=1.18 (95% CI, 1.10-1.26) for daily seizures; RR=1.22 (95% CI, 1.10-1.35) for weekly seizures and RR=1.15 (95% CI, 1.03-1.28) for monthly seizures)).; EEG abnormalities are common in Africans with epilepsy and are associated with preventable risk factors.; EEG is helpful in identifying focal epilepsy in Africa, where timing of focal aetiologies is problematic and there is a lack of neuroimaging services.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Eco System Health Sciences > Helminths and Health (Odermatt)
UniBasel Contributors:Odermatt, Peter
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:1388-2457
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:30 Jun 2016 11:03
Deposited On:28 Apr 2016 09:25

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