Broz, Petr and Dixit, Vishva M.. (2016) Inflammasomes: mechanism of assembly, regulation and signalling. Nature reviews. Immunology, 16 (7). pp. 407-420.
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Official URL: http://edoc.unibas.ch/43417/
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Abstract
Inflammasomes are multiprotein signalling platforms that control the inflammatory response and coordinate antimicrobial host defences. They are assembled by pattern-recognition receptors following the detection of pathogenic microorganisms and danger signals in the cytosol of host cells, and they activate inflammatory caspases to produce cytokines and to induce pyroptotic cell death. The clinical importance of inflammasomes reaches beyond infectious disease, as dysregulated inflammasome activity is associated with numerous hereditary and acquired inflammatory disorders. In this Review, we discuss the recent developments in inflammasome research with a focus on the molecular mechanisms that govern inflammasome assembly, signalling and regulation.
Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Infection Biology (Broz) |
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UniBasel Contributors: | Broz, Petr |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Nature Publishing Group |
ISSN: | 1474-1733 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Identification Number: |
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Last Modified: | 13 Dec 2016 10:15 |
Deposited On: | 13 Dec 2016 10:15 |
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