Iridium-Catalyzed asymmetric hydrogenation : A: Studies on the synthesis of pyrazine-based P,N Ligands, B: Diastereoselective hydrogenation of chiral cyclohexenes

The synthesis of a new ligand class of pyrazine based ligands and their attempted complexation with iridium to form dimeric complexes is presented. Furthermore, the synthesis of chiral cyclohexenes by enantioselective Diels-Alder reactions is shown. These substrates were tested in the diastereoselective reduction by a chiral iridium catalyst. Last, some results of enantioselective palladium-catalyzed allylic substitution reactions and asymmetric iridium-catalyzed hydrogenation with different NeoPHOX ligands are presented.