edoc-vmtest

Intra-arterial catheter guided steroid administration for the treatment of steroid-refractory intestinal GvHD

Bürgler, David and Medinger, Michael and Passweg, Jakob and Fischmann, Arne and Bucher, Christoph. (2014) Intra-arterial catheter guided steroid administration for the treatment of steroid-refractory intestinal GvHD. Leukemia Research, 38 (2). pp. 184-187.

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Official URL: http://edoc.unibas.ch/43910/

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Abstract

Acute gastrointestinal GvHD (GI-aGvHD) refractory to first-line treatment with systemic corticosteroids is resulting in death in the majority of patients. We prospectively assessed the feasibility and efficacy of regional intra-arterial steroid treatment in adult patients with severe (≥ grade III) GI-aGvHD not responding to first-line treatment.; Patients with more than +++ GI-aGvHD not responding to intravenous methylprednisolone at a dose of 2mg/kg/day were eligible for inclusion. Catheter guided intra-arterial steroid administration (IASA) was performed into the superior and inferior mesenteric artery.; 12 consecutive patients with steroid-refractory grade III GI-aGvHD received IASA as second-line treatment. 83% of patients had gastrointestinal response including four patients (33%) with complete response at 28 days after IASA. 5/12 patients were alive at a median time of 531 days.; Regional treatment of severe GVHD with IASA treatment seems to be a safe and effective second-line treatment for steroid-refractory GI-aGvHD in adult patients.
Faculties and Departments:03 Faculty of Medicine
UniBasel Contributors:Medinger, Michael
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0145-2126
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:04 Oct 2017 08:51
Deposited On:04 Oct 2017 08:51

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