Witzigmann, Dominik and Detampel, Pascal and Porta, Fabiola and Huwyler, Jörg. (2016) Isolation of Multiantennary N-Glycans from Glycoproteins for Hepatocyte Specific Targeting via the Asialoglycoprotein Receptor. RSC Advances, 6. pp. 97636-97640.
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Abstract
The asialoglycoprotein receptor (ASGPR) expressed on parenchymal liver cells specifically binds multivalent carbohydrates from desialylated glycoproteins. This feature offers a huge potential for hepatocyte specific drug targeting. In this study, multiantennary N-glycans from asialofetuin have been isolated to actively target the asialoglycoprotein receptor on human hepatocellular carcinoma cells in vitro.
| Faculties and Departments: | 05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmaceutical Technology (Huwyler) |
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| UniBasel Contributors: | Huwyler, Jörg and Detampel, Pascal and Witzigmann, Dominik and Porta, Fabiola |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Royal Society of Chemistry |
| e-ISSN: | 2046-2069 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 31 Oct 2017 10:38 |
| Deposited On: | 31 Oct 2017 10:38 |
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