Sellmeijer, Jim. The ACC is a critical hub for neuropathic pain- induced depression. 2016, Doctoral Thesis, University of Basel, Faculty of Science.
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Official URL: http://edoc.unibas.ch/diss/DissB_11965
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Abstract
Besides chronic stress, chronic pain is one of the prevalent determinants for depression. Indeed,
around 50% of chronic pain patients develop mood disorders. Alterations in brain regions
implicated in pain processing may also be involved in affective processing, thus potentially be
responsible of mood disorders. However, the underlying mechanisms of this comorbidity are not
yet elucidated. Here, we studied the role of the anterior cingulate cortex (ACC) in the
somatosensory, aversive and anxiodepressive consequences of neuropathic pain. We showed that
a permanent lesion or temporal inhibition of ACC pyramidal neurons blocked the development or
suppressed the expression of an anxiodepressive phenotype in neuropathic mice. In addition,
anxiodepressive-like behavior coincided with ACC hyperactivity. In conclusion we show that the
ACC is a critical hub for neuropathic pain-induced depression.
around 50% of chronic pain patients develop mood disorders. Alterations in brain regions
implicated in pain processing may also be involved in affective processing, thus potentially be
responsible of mood disorders. However, the underlying mechanisms of this comorbidity are not
yet elucidated. Here, we studied the role of the anterior cingulate cortex (ACC) in the
somatosensory, aversive and anxiodepressive consequences of neuropathic pain. We showed that
a permanent lesion or temporal inhibition of ACC pyramidal neurons blocked the development or
suppressed the expression of an anxiodepressive phenotype in neuropathic mice. In addition,
anxiodepressive-like behavior coincided with ACC hyperactivity. In conclusion we show that the
ACC is a critical hub for neuropathic pain-induced depression.
| Advisors: | Luthi, Andreas and Aertsen, Ad and Yalçın-Christmann, İpek |
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| Faculties and Departments: | 09 Associated Institutions > Friedrich Miescher Institut FMI > Neurobiology > Cellular mechanisms of learning and memory (Lüthi) |
| Item Type: | Thesis |
| Thesis Subtype: | Doctoral Thesis |
| Thesis no: | 11965 |
| Thesis status: | Complete |
| Number of Pages: | 1 Online-Ressource (113 Seiten) |
| Language: | English |
| Identification Number: |
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| edoc DOI: | |
| Last Modified: | 24 Sep 2020 21:32 |
| Deposited On: | 21 Dec 2016 12:44 |
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