Biehlmaier, O. and Alam, M. and Schmidt, W. J.. (2007) A rat model of Parkinsonism shows depletion of dopamine in the retina. Neurochemistry International, 50 (1). pp. 189-195.
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Official URL: http://edoc.unibas.ch/45812/
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Abstract
The retinal dopamine (DA) deficiency is an important feature of the pathogenesis in Parkinson`s disease (PD) visual dysfunction. Systemic inhibition of complex I (rotenone) in rats has been proposed as a model of PD. In this study, we investigated whether systemic inhibition of complex I can induce impairment of DA-ergic cells in the retina, similar to the destruction of retinal cells found in PD patients. Rotenone (2.5mg/kg i.p., daily) was administered over 60 days. Neurochemically, rotenone treated rats showed a depletion of DA in the striatum and substantia nigra (SN). In addition, the number of retinal DA-ergic amacrine cells was significantly reduced in the rotenone treated animals. This study is the first one giving highlight towards a deeper understanding of systemic complex I inhibition (rotenone as an environmental toxin) and the connection between both, DA-ergic degeneration in the nigrostriatal pathway, and in the DA-ergic amacrine cells of the retina.
| Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Imaging Core Facility (Biehlmaier) |
|---|---|
| UniBasel Contributors: | Biehlmaier, Oliver |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Elsevier |
| ISSN: | 0197-0186 |
| e-ISSN: | 1872-9754 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 28 Nov 2017 08:26 |
| Deposited On: | 28 Nov 2017 08:26 |
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