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PhosphoPep-a phosphoproteome resource for systems biology research in Drosophila Kc167 cells

Bodenmiller, Bernd and Malmstrom, Johan and Gerrits, Bertran and Campbell, David and Lam, Henry and Schmidt, Alexander and Rinner, Oliver and N. Mueller, Lukas and T. Shannon, Paul and G. Pedrioli, Patrick and Panse, Christian and Lee, Hoo-Keun and Schlapbach, Ralph and Aebersold, Ruedi . (2007) PhosphoPep-a phosphoproteome resource for systems biology research in Drosophila Kc167 cells. Molecular Systems Biology, 3 (1). p. 139.

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Official URL: http://edoc.unibas.ch/45906/

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Abstract

The ability to analyze and understand the mechanisms by which cells process information is a key question of systems biology research. Such mechanisms critically depend on reversible phosphorylation of cellular proteins, a process that is catalyzed by protein kinases and phosphatases. Here, we present PhosphoPep, a database containing more than 10 000 unique high-confidence phosphorylation sites mapping to nearly 3500 gene models and 4600 distinct phosphoproteins of the Drosophila melanogaster Kc167 cell line. This constitutes the most comprehensive phosphorylation map of any single source to date. To enhance the utility of PhosphoPep, we also provide an array of software tools that allow users to browse through phosphorylation sites on single proteins or pathways, to easily integrate the data with other, external data types such as protein-protein interactions and to search the database via spectral matching. Finally, all data can be readily exported, for example, for targeted proteomics approaches and the data thus generated can be again validated using PhosphoPep, supporting iterative cycles of experimentation and analysis that are typical for systems biology research.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Proteomics (Schmidt)
UniBasel Contributors:Schmidt, Alexander
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:EMBO
ISSN:1744-4292
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:28 Nov 2017 08:21
Deposited On:28 Nov 2017 08:21

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