The neuronal transporter gene SLC6A15 confers risk to major depression

Kohli, Martin A. and Lucae, Susanne and Saemann, Philipp G. and Schmidt, Mathias V. and Demirkan, Ayse and Hek, Karin and Czamara, Darina and Alexander, Michael and Salyakina, Daria and Ripke, Stephan and Hoehn, David and Specht, Michael and Menke, Andreas and Hennings, Johannes and Heck, Angela and Wolf, Christiane and Ising, Marcus and Schreiber, Stefan and Czisch, Michael and Müller, Marianne B. and Uhr, Manfred and Bettecken, Thomas and Becker, Albert and Schramm, Johannes and Rietschel, Marcella and Maier, Wolfgang and Bradley, Bekh and Ressler, Kerry J. and Nöthen, Markus M. and Cichon, Sven and Craig, Ian W. and Breen, Gerome and Lewis, Cathryn M. and Hofman, Albert and Tiemeier, Henning and van Duijn, Cornelia M. and Holsboer, Florian and Müller-Myhsok, Bertram and Binder, Elisabeth B.. (2011) The neuronal transporter gene SLC6A15 confers risk to major depression. Neuron, 70 (2). pp. 252-265.

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Official URL: http://edoc.unibas.ch/47311/

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Abstract

Major depression (MD) is one of the most prevalent psychiatric disorders and a leading cause of loss in work productivity. A combination of genetic and environmental risk factors probably contributes to MD. We present data from a genome-wide association study revealing a neuron-specific neutral amino acid transporter (SLC6A15) as a susceptibility gene for MD. Risk allele carrier status in humans and chronic stress in mice were associated with a downregulation of the expression of this gene in the hippocampus, a brain region implicated in the pathophysiology of MD. The same polymorphisms also showed associations with alterations in hippocampal volume and neuronal integrity. Thus, decreased SLC6A15 expression, due to genetic or environmental factors, might alter neuronal circuits related to the susceptibility for MD. Our convergent data from human genetics, expression studies, brain imaging, and animal models suggest a pathophysiological mechanism for MD that may be accessible to drug targeting.

Faculties and Departments:	07 Faculty of Psychology > Departement Psychologie
UniBasel Contributors:	Heck, Angela
Item Type:	Article, refereed
Article Subtype:	Research Article
Publisher:	Elsevier
ISSN:	0896-6273
e-ISSN:	1097-4199
Note:	Publication type according to Uni Basel Research Database: Journal article
Identification Number:	pmid: 21521612
Last Modified:	30 Nov 2017 08:04
Deposited On:	30 Nov 2017 08:04

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