Stallforth, Pierre and Matthies, Stefan and Adibekian, Alexander and Gillingham, Dennis and Hilvert, Donald and Seeberger, Peter. (2012) De novo chemoenzymatic synthesis of sialic acid. Chemical Communications, 48 (98). pp. 11987-11989.
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Official URL: http://edoc.unibas.ch/48462/
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Abstract
A chemoenzymatic synthesis of sialic acid from inexpensive N -acetyl- D -glucosamine is described. In a three-step Wittig–protection–ozonolysis strategy manno -configured aldehydes are obtained. Treatment with oxaloacetate in the presence of macrophomate synthase affords the signature α-keto-γ-hydroxy acid moiety with high diastereoselectivity.
| Faculties and Departments: | 05 Faculty of Science > Departement Chemie > Chemie > Organische Chemie (Gillingham) |
|---|---|
| UniBasel Contributors: | Gillingham, Dennis |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1359-7345 |
| e-ISSN: | 1364-548X |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 17 Mar 2017 13:43 |
| Deposited On: | 05 Jan 2017 11:05 |
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