Puri, Aaron W. and Broz, Petr and Shen, Aimee and Monack, Denise M. and Bogyo, Matthew. (2012) Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection. Nature Chemical Biology, 8 (9). pp. 745-747.
Full text not available from this repository.
Official URL: http://edoc.unibas.ch/48479/
Downloads: Statistics Overview
Abstract
Here we report AWP28, an activity-based probe that can be used to biochemically monitor caspase-1 activation in response to proinflammatory stimuli. Using AWP28, we show that apoptosis is triggered upon Salmonella enterica var. Typhimurium infection in primary mouse bone marrow macrophages lacking caspase-1. Furthermore, we report that upon Salmonella infection, inflammasome-mediated caspase-1 activity is required to bypass apoptosis in favor of proinflammatory pyroptotic cell death.
Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Infection Biology |
---|---|
UniBasel Contributors: | Broz, Petr |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Nature Publishing Group |
ISSN: | 1552-4450 |
e-ISSN: | 1552-4469 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Identification Number: |
|
Last Modified: | 30 Nov 2017 11:20 |
Deposited On: | 30 Nov 2017 11:20 |
Repository Staff Only: item control page