Thamm, Irene and Richers, Johannes and Rychlik, Michael and Tiefenbacher, Konrad. (2016) A six-step total synthesis of α-thujone and d6-α-thujone, enabling facile access to isotopically labelled metabolites. Chemical Communications, 52 (78). pp. 11701-11703.
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Abstract
The short synthesis of alpha-thujone relies on the functionalization of the readily available dimethylfulvene. Furthermore, the three main metabolites of the natural product were also synthesized. Since d(6)-acetone can be used as a starting material, the route developed allows for the facile incorporation of isotopic labels which are required for detecting and quantifying trace amounts via GC/MS analysis.
| Faculties and Departments: | 05 Faculty of Science > Departement Chemie > Chemie > Organische Chemie (Sparr) 05 Faculty of Science > Departement Chemie > Chemie > Synthesis of Functional Modules (Tiefenbacher) |
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| UniBasel Contributors: | Tiefenbacher, Konrad Karl |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1359-7345 |
| e-ISSN: | 1364-548X |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 14 Jun 2017 09:26 |
| Deposited On: | 14 Jun 2017 09:26 |
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