Furrer, Regula and Eisele, Petra S. and Schmidt, Alexander and Beer, Markus and Handschin, Christoph. (2017) Paracrine cross-talk between skeletal muscle and macrophages in exercise by PGC-1α-controlled BNP. Scientific Reports, 7. p. 40789.
PDF
- Published Version
Available under License CC BY (Attribution). 1508Kb | |
PDF
Restricted to Repository staff only 1508Kb |
Official URL: http://edoc.unibas.ch/53281/
Downloads: Statistics Overview
Abstract
Activation of resident and infiltrating immune cells is a central event in training adaptation and other contexts of skeletal muscle repair and regeneration. A precise orchestration of inflammatory events in muscle fibers and immune cells is required after recurrent contraction-relaxation cycles. However, the mechanistic aspects of this important regulation remain largely unknown. We now demonstrate that besides a dominant role in controlling cellular metabolism, the peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) also has a profound effect on cytokine expression in muscle tissue. Muscle PGC-1α expression results in activation of tissue-resident macrophages, at least in part mediated by PGC-1α-dependent B-type natriuretic peptide (BNP) production and secretion. Positive effects of exercise in metabolic diseases and other pathologies associated with chronic inflammation could accordingly involve the PGC-1α-BNP axis and thereby provide novel targets for therapeutic approaches.
Faculties and Departments: | 03 Faculty of Medicine > Departement Biomedizin > Associated Research Groups > Pharmakologie (Handschin) 05 Faculty of Science > Departement Biozentrum > Growth & Development > Growth & Development (Handschin) |
---|---|
UniBasel Contributors: | Handschin, Christoph and Schmidt, Alexander |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Nature Publishing Group |
e-ISSN: | 2045-2322 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Language: | English |
Language: | English |
Identification Number: |
|
edoc DOI: | |
Last Modified: | 26 Jan 2018 04:19 |
Deposited On: | 25 Sep 2017 14:47 |
Repository Staff Only: item control page