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Cutting edge: human gamma delta T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis

Altincicek, B. and Moll, J. and Campos, N. and Foerster, G. and Beck, E. and Hoeffler, J. F. and Grosdemange-Billiard, C. and Rodríguez-Concepción, M. and Rohmer, M. and Boronat, A. and Eberl, M. and Jomaa, H.. (2001) Cutting edge: human gamma delta T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis. Journal of Immunology, 166 (6). pp. 3655-3658.

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Official URL: http://edoc.unibas.ch/53323/

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Abstract

Activation of V gamma 9/V delta 2 T cells by small nonprotein Ags is frequently observed after infection with various viruses, bacteria, and eukaryotic parasites. We suggested earlier that compounds synthesized by the 2-C:-methyl-D-erythritol 4-phosphate (MEP) pathway of isopentenyl pyrophosphate synthesis are responsible for the V gamma 9/V delta 2 T cell reactivity of many pathogens. Using genetically engineered Escherichia coli knockout strains, we now demonstrate that the ability of E. coli extracts to stimulate gamma delta T cell proliferation is abrogated when genes coding for essential enzymes of the MEP pathway, dxr or gcpE, are disrupted or deleted from the bacterial genome.
Faculties and Departments:03 Faculty of Medicine > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > Anästhesie (Frei/Erb)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > Anästhesie (Frei/Erb)
UniBasel Contributors:Moll, Jens
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Association of Immunologists
ISSN:0022-1767
e-ISSN:1550-6606
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:27 Nov 2017 10:14
Deposited On:27 Nov 2017 10:14

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