Moritz, Steffen and Kolbeck, Katharina and Andreou, Christina. (2016) Antipsychotics decrease response confidence. Journal of Psychopharmacology, 30 (8). pp. 831-833.
Full text not available from this repository.
Official URL: http://edoc.unibas.ch/53816/
Downloads: Statistics Overview
Abstract
Antipsychotics represent the first-choice treatment for schizophrenia. However, the cognitive and emotional pathways through which symptom reduction is achieved have remained unclear. We recently proposed that the induction of doubt is a core mechanism of action of antipsychotics. In the framework of a randomized, double-blind, placebo-controlled, crossover design, 39 nonclinical participants filled out a questionnaire tapping into cognitive and emotional changes (Effect of Antipsychotic Medication on Emotion and Cognition-revised (EAMEC-r)) each time they had received one of three substances (haloperidol, placebo, L-dopa). Participants reported more doubt under haloperidol than under L-dopa lending support to the theory that antipsychotics decrease delusional conviction via the reduction of confidence. Key points from this study are: (a) antipsychotics induce doubt, and (b) doubt may represent a core mechanism of action for the reduction of delusional ideas.
Faculties and Departments: | 03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler) |
---|---|
UniBasel Contributors: | Andreou, Christina |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | SAGE Publications |
ISSN: | 0269-8811 |
e-ISSN: | 1461-7285 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Identification Number: |
|
Last Modified: | 05 Oct 2017 10:27 |
Deposited On: | 05 Oct 2017 10:27 |
Repository Staff Only: item control page