Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

Stucki, David and Brites, Daniela and Jeljeli, Leïla and Coscolla, Mireia and Liu, Qingyun and Trauner, Andrej and Fenner, Lukas and Rutaihwa, Liliana and Borrell, Sonia and Luo, Tao and Gao, Qian and Kato-Maeda, Midori and Ballif, Marie and Egger, Matthias and Macedo, Rita and Mardassi, Helmi and Moreno, Milagros and Vilanova, Griselda Tudo and Fyfe, Janet and Globan, Maria and Thomas, Jackson and Jamieson, Frances and Guthrie, Jennifer L. and Asante-Poku, Adwoa and Yeboah-Manu, Dorothy and Wampande, Eddie and Ssengooba, Willy and Joloba, Moses and Boom, W. Henry and Basu, Indira and Bower, James and Saraiva, Margarida and Vasconcellos, Sidra E. G. and Suffys, Philip and Koch, Anastasia and Wilkinson, Robert and Gail-Bekker, Linda and Malla, Bijaya and Ley, Serej D. and Beck, Hans-Peter and de Jong, Bouke C. and Toit, Kadri and Sanchez-Padilla, Elisabeth and Bonnet, Maryline and Gil-Brusola, Ana and Frank, Matthias and Penlap Beng, Veronique N. and Eisenach, Kathleen and Alani, Issam and Ndung'u, Perpetual Wangui and Revathi, Gunturu and Gehre, Florian and Akter, Suriya and Ntoumi, Francine and Stewart-Isherwood, Lynsey and Ntinginya, Nyanda E. and Rachow, Andrea and Hoelscher, Michael and Cirillo, Daniela Maria and Skenders, Girts and Hoffner, Sven and Bakonyte, Daiva and Stakenas, Petras and Diel, Roland and Crudu, Valeriu and Moldovan, Olga and Al-Hajoj, Sahal and Otero, Larissa and Barletta, Francesca and Carter, E. Jane and Diero, Lameck and Supply, Philip and Comas, Iñaki and Niemann, Stefan and Gagneux, Sebastien. (2016) Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages. Nature genetics, 48 (12). pp. 1535-1543.

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Abstract

Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.

Faculties and Departments:	09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Tuberculosis Ecology and Evolution Unit (Gagneux)
UniBasel Contributors:	Stucki, David and Brites, Daniela and Coscollá, Mireja and Fenner, Lukas and Borrell, Sonia and Ballif, Marie and Beck, Hans-Peter and Gagneux, Sebastien
Item Type:	Article, refereed
Article Subtype:	Research Article
Publisher:	Nature Publ
ISSN:	1061-4036
Note:	Publication type according to Uni Basel Research Database: Journal article
Identification Number:	doi: 10.1038/ng.3704 pmid: 27798628
Last Modified:	20 Apr 2017 12:51
Deposited On:	20 Apr 2017 12:51

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