Walburger, A. and Koul, A. and Ferrari, G. and Nguyen, L. and Prescianotto-Baschong, C. and Huygen, K. and Klebl, B. and Thompson, C. and Bacher, G. and Pieters, J.. (2004) Protein kinase G from pathogenic mycobacteria promotes survival within macrophages. Science, 304 (5678). pp. 1800-1804.
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Official URL: http://edoc.unibas.ch/dok/A5259409
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Abstract
Pathogenic mycobacteria resist lysosomal delivery after uptake into macrophages, allowing them to survive intracellularly. We found that the eukaryotic-like serine/threonine protein kinase G from pathogenic mycobacteria was secreted within macrophage phagosomes, inhibiting phagosome-lysosome fusion and mediating intracellular survival of mycobacteria. Inactivation of protein kinase G by gene disruption or chemical inhibition resulted in lysosomal localization and mycobacterial cell death in infected macrophages. Besides identifying a target for the control of mycobacterial infections, these findings suggest that pathogenic mycobacteria have evolved eukaryotic-like signal transduction mechanisms capable of modulating host cell trafficking pathways.
Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Infection Biology > Biochemistry (Pieters) |
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UniBasel Contributors: | Pieters, Jean |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | American Association for the Advancement of Science |
ISSN: | 0036-8075 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Language: | English |
Identification Number: | |
edoc DOI: | |
Last Modified: | 25 Sep 2017 10:04 |
Deposited On: | 22 Mar 2012 13:30 |
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