Kamena, F. and Spang, A.. (2004) Tip20p prohibits back-fusion of COPII vesicles with the endoplasmic reticulum. Science, 304 (5668). pp. 286-289.
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Official URL: http://edoc.unibas.ch/dok/A5259754
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Abstract
Directionality in intracellular trafficking is essential to ensure the correct localization of proteins along the secretory pathway. Here, we found evidence for an active mechanism that prohibited back-fusion of de novo-generated vesicles with their donor compartment. Tip20p is a peripheral membrane protein implicated in consumption of COPI vesicles at the endoplasmic reticulum. However, a specific mutant of TIP20 did not interfere with COPII vesicle generation but allowed these vesicles to fuse back to the endoplasmic reticulum, a process that does not occur normally in the cell.
| Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Spang) |
|---|---|
| UniBasel Contributors: | Spang, Anne |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | American Association for the Advancement of Science |
| ISSN: | 0036-8075 |
| e-ISSN: | 1095-9203 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: | |
| Last Modified: | 16 Nov 2017 15:31 |
| Deposited On: | 22 Mar 2012 13:30 |
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