Vieira, Eric and Huwyler, Jörg and Jolidon, Synèse and Knoflach, Frédéric and Mutel, Vincent and Wichmann, Jürgen. (2009) Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers. Bioorganic and Medicinal Chemistry Letters, 19 (6). pp. 1666-1669.
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Official URL: http://edoc.unibas.ch/54617/
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Abstract
Small molecule mGluR1 enhancers, which are 9H-xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides, have been previously reported. Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides with improved pharmacokinetic properties have been designed and synthesized as useful pharmacological tools for the study of the physiological roles mediated by mGlu1 receptors. The synthesis and the structure-activity relationship of this class of positive allosteric modulators of mGlu1 receptors will be discussed in detail.
| Faculties and Departments: | 05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmaceutical Technology (Huwyler) |
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| UniBasel Contributors: | Huwyler, Jörg |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Elsevier |
| ISSN: | 0960-894X |
| e-ISSN: | 1464-3405 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 29 Nov 2017 07:55 |
| Deposited On: | 29 Nov 2017 07:55 |
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