Ceccarelli, Simona M. and Jaeschke, Georg and Buettelmann, Bernd and Huwyler, Jörg and Kolczewski, Sabine and Peters, Jens-Uwe and Prinssen, Eric and Porter, Richard and Spooren, Will and Vieira, Eric. (2007) Rational design, synthesis, and structure-activity relationship of benzoxazolones: new potent mglu5 receptor antagonists based on the fenobam structure. Bioorganic and Medicinal Chemistry Letters, 17 (5). pp. 1302-1306.
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Official URL: http://edoc.unibas.ch/54626/
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Abstract
A novel class of potent and stable mGlu5 receptor antagonists was developed by combining information from a high-throughput screening campaign with the structure of the known anxiolytic fenobam. Representative compounds from this class show favorable pharmacokinetic properties and are active in an in vivo model of anxiety.
| Faculties and Departments: | 05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmaceutical Technology (Huwyler) |
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| UniBasel Contributors: | Huwyler, Jörg |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Elsevier |
| ISSN: | 0960-894X |
| e-ISSN: | 1464-3405 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 28 Nov 2017 07:39 |
| Deposited On: | 28 Nov 2017 07:39 |
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