edoc-vmtest

Bacterial microbiota of the upper respiratory tract and childhood asthma

Depner, Martin and Ege, Markus J. and Cox, Michael J. and Dwyer, Sarah and Walker, Alan W. and Birzele, Lena T. and Genuneit, Jon and Horak, Elisabeth and Braun-Fahrländer, Charlotte and Danielewicz, Hanna and Maier, Raina M. and Moffatt, Miriam F. and Cookson, William O. and Heederik, Dick and von Mutius, Erika and Legatzki, Antje. (2017) Bacterial microbiota of the upper respiratory tract and childhood asthma. Journal of allergy and clinical immunology, 139 (3). pp. 826-834.e13.

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Official URL: http://edoc.unibas.ch/54727/

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Abstract

Patients with asthma and healthy controls differ in bacterial colonization of the respiratory tract. The upper airways have been shown to reflect colonization of the lower airways, the actual site of inflammation in asthma, which is hardly accessible in population studies.; We sought to characterize the bacterial communities at 2 sites of the upper respiratory tract obtained from children from a rural area and to relate these to asthma.; The microbiota of 327 throat and 68 nasal samples from school-age farm and nonfarm children were analyzed by 454-pyrosequencing of the bacterial 16S ribosomal RNA gene.; Alterations in nasal microbiota but not of throat microbiota were associated with asthma. Children with asthma had lower α- and β-diversity of the nasal microbiota as compared with healthy control children. Furthermore, asthma presence was positively associated with a specific operational taxonomic unit from the genus Moraxella in children not exposed to farming, whereas in farm children Moraxella colonization was unrelated to asthma. In nonfarm children, Moraxella colonization explained the association between bacterial diversity and asthma to a large extent.; Asthma was mainly associated with an altered nasal microbiota characterized by lower diversity and Moraxella abundance. Children living on farms might not be susceptible to the disadvantageous effect of Moraxella. Prospective studies may clarify whether Moraxella outgrowth is a cause or a consequence of loss in diversity.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Environmental Exposures and Health Systems Research > Physical Hazards and Health (Röösli)
UniBasel Contributors:Braun-Fahrländer, Charlotte
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Mosby
ISSN:0091-6749
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:27 Oct 2017 11:04
Deposited On:23 May 2017 09:31

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